Intravesical VesiX as a Last Resort Therapy in Women With Antibiotic-Refractory Recurrent Urinary Tract Infections Contemplating Bladder Removal: A Preliminary Report
Philippe E Zimmern, Namrata V Sawant, Samuel S Chang, Randolph W Warner, Nicole J De Nisco
An article published in the Journal of Urology in 19451 reported on the use of cetylpyridinium chloride (CPC) as a renal pelvic lavage to treat urinary tract infection (UTI). The publication detailed the renal lavage technique at a dilution of 1:10 000 in 35 patients treated over 1 year. The author commented that “some of the bladder and urethral infections cleared up after its use”1 with no evidence of irritation. The advent of antibiotics has since supplanted all non-antibiotic approaches for the management of UTI. However, with the alarming recent increase in antibiotic allergies and resistance,2,3 along with an aging population,4-6 older UTI therapies, including intravesical instillations,7 are being revisited.
CPC has been extensively used as an antimicrobial agent in both eye drops and oral rinses. Given its long history of use in humans and the prior report of its application to treat UTI,1 our group has begun investigating the efficacy of intravesical instillation of VesiX, a CPC-based antimicrobial agent, for treatment of antibiotic-recalcitrant recurrent UTI (rUTI) in postmenopausal women.
https://journals.sagepub.com/doi/10.1177/10600280221112111?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed